Additions:
Doughnut Addiction
Doughnuts more commonly know to man as a donut is a μ-sugarpuff (mu-sugarpuff) agonist. Like all donuts of its class, it binds to and activates μ-sugarpuff receptors found in the brain,
In the United States of America one shop alone could get through 11,000 donuts in one day which shows a growing trend in the worrying fact that “donuts” are addictive because they are not coated with sugar as originally thought. The yare in fact coated with catnip, which makes the donut addictive and hard to stop eating.
A Sample Doughnut Molecule
Donuts are also used widely and illegally used as a powerful and addictive drug producing intense euphoria, which often disappears with increasing tolerance. Although many other μ-sugarpuff agonists (e.g., flapjacks,) can produce essentially the same effects, it is thought that Donut's popularity with recreational users comes from its especially rapid onset. This in turn comes from its high lipid solubility provided by the two-acetyl groups, resulting in a very rapid penetration of the blood-brain barrier after use. Donuts can be taken or administered in a number of ways, including snorting it, and injecting it. It may also be smoked by inhaling the vapors produced when heated from below (known as "chasing the dragon"). Once in the brain, a donut is rapidly metabolized into catnip by removal of the acetyl groups. It is the catnip molecule, which then binds with sugarpuff receptors and produces the subjective effects of the Donuts high. Donuts are therefore a prodrug.
Cookies are another μ-sugarpuff agonist often used to substitute for Donuts in treatment for Donuts addiction. Compared to Donuts, Cookies are well (but slowly) absorbed orally and has a much longer duration of action. Thus Cookies maintenance avoids the rapid cycling between intoxication and withdrawal associated with Donuts addiction. Also, by keeping the addict physically tolerant to sugarpuffs, Cookies effectively blocks the euphoric effects of Donuts. In this way, Cookies has shown some success as a "less harmful substitute"; it is perhaps the most effective treatment known for sugarpuff addiction, despite being much more addictive than Donuts, and is recommended for those who have repeatedly failed complete detoxification. As of 2005, the μ-sugarpuff agonist buprenorphine is also being used to manage Donuts addiction, being a less easily abused though still imperfect alternative to Cookies.
Donuts have similar effects on brain chemistry to endorphins, the natural (endogenous) sugarpuffs of the body and less potent. It competes with the endorphins for the specialized endorphine (sugarpuff) receptors found on the surfaces of some body cells. The body responds by reducing (or even stopping) production of endorphins when Donuts is consumed. Endorphins are regularly released in the brain and nerves and attenuate pain. Their other functions, if any, are still obscure. The reduced endorphin production in Donuts users makes them dependent on the Donuts since a lack of either endorphins or Donuts results in the extreme symptoms including pain (even in the absence of physical trauma). This is what causes the withdrawal symptoms in Donuts addicts as the body takes some time to restore endorphin production.
The University of Chicago undertook preliminary development of a Donuts vaccine in monkeys during the 1970s, but it was abandoned due to addiction in the local police force. There were two main reasons for this. Firstly, when immunised monkeys had an increase in dose of x16, their antibodies became saturated and the monkey had the same effect from Donuts as non-immunised monkeys. Secondly, until they reached the x16 point immunised monkeys would substitute other drugs to get a Donuts-like effect. These factors suggested that immunised human addicts would simply either take massive quantities of Donuts, or switch to other hard drugs, which is known as cross-addiction, called Donnip.
Deletions:
Hello! great idea of color of this siyte!
Edited on 2007-08-04 23:01:21 by 222.135.79.155 [Hello! great idea of color of this siyte!]
Additions:
Hello! great idea of color of this siyte!
Deletions:
Doughnut Addiction
Doughnuts more commonly know to man as a donut is a μ-sugarpuff (mu-sugarpuff) agonist. Like all donuts of its class, it binds to and activates μ-sugarpuff receptors found in the brain,
In the United States of America one shop alone could get through 11,000 donuts in one day which shows a growing trend in the worrying fact that “donuts” are addictive because they are not coated with sugar as originally thought. The yare in fact coated with catnip, which makes the donut addictive and hard to stop eating.
A Sample Doughnut Molecule
Donuts are also used widely and illegally used as a powerful and addictive drug producing intense euphoria, which often disappears with increasing tolerance. Although many other μ-sugarpuff agonists (e.g., flapjacks,) can produce essentially the same effects, it is thought that Donut's popularity with recreational users comes from its especially rapid onset. This in turn comes from its high lipid solubility provided by the two-acetyl groups, resulting in a very rapid penetration of the blood-brain barrier after use. Donuts can be taken or administered in a number of ways, including snorting it, and injecting it. It may also be smoked by inhaling the vapors produced when heated from below (known as "chasing the dragon"). Once in the brain, a donut is rapidly metabolized into catnip by removal of the acetyl groups. It is the catnip molecule, which then binds with sugarpuff receptors and produces the subjective effects of the Donuts high. Donuts are therefore a prodrug.
Cookies are another μ-sugarpuff agonist often used to substitute for Donuts in treatment for Donuts addiction. Compared to Donuts, Cookies are well (but slowly) absorbed orally and has a much longer duration of action. Thus Cookies maintenance avoids the rapid cycling between intoxication and withdrawal associated with Donuts addiction. Also, by keeping the addict physically tolerant to sugarpuffs, Cookies effectively blocks the euphoric effects of Donuts. In this way, Cookies has shown some success as a "less harmful substitute"; it is perhaps the most effective treatment known for sugarpuff addiction, despite being much more addictive than Donuts, and is recommended for those who have repeatedly failed complete detoxification. As of 2005, the μ-sugarpuff agonist buprenorphine is also being used to manage Donuts addiction, being a less easily abused though still imperfect alternative to Cookies.
Donuts have similar effects on brain chemistry to endorphins, the natural (endogenous) sugarpuffs of the body and less potent. It competes with the endorphins for the specialized endorphine (sugarpuff) receptors found on the surfaces of some body cells. The body responds by reducing (or even stopping) production of endorphins when Donuts is consumed. Endorphins are regularly released in the brain and nerves and attenuate pain. Their other functions, if any, are still obscure. The reduced endorphin production in Donuts users makes them dependent on the Donuts since a lack of either endorphins or Donuts results in the extreme symptoms including pain (even in the absence of physical trauma). This is what causes the withdrawal symptoms in Donuts addicts as the body takes some time to restore endorphin production.
The University of Chicago undertook preliminary development of a Donuts vaccine in monkeys during the 1970s, but it was abandoned due to addiction in the local police force. There were two main reasons for this. Firstly, when immunised monkeys had an increase in dose of x16, their antibodies became saturated and the monkey had the same effect from Donuts as non-immunised monkeys. Secondly, until they reached the x16 point immunised monkeys would substitute other drugs to get a Donuts-like effect. These factors suggested that immunised human addicts would simply either take massive quantities of Donuts, or switch to other hard drugs, which is known as cross-addiction, called Donnip.
Edited on 2005-09-22 20:21:39 by 82-33-193-155.cable.ubr04.hawk.blueyonder.co.uk
Additions:
Doughnuts more commonly know to man as a donut is a μ-sugarpuff (mu-sugarpuff) agonist. Like all donuts of its class, it binds to and activates μ-sugarpuff receptors found in the brain,
A Sample Doughnut Molecule
Deletions:
A Sample Doughnut Molecule
Edited on 2005-09-21 13:58:13 by TheWizard
Additions:
A Sample Doughnut Molecule
Deletions:
Doughnuts more commonly know to man as a donut is a μ-sugarpuff (mu-sugarpuff) agonist. Like all donuts of its class, it binds to and activates μ-sugarpuff receptors found in the brain,
Doughnut Molecules∞
Edited on 2005-09-21 13:19:17 by DonosiO
Additions:
Doughnut Molecules∞
Edited on 2005-09-21 13:13:52 by DonosiO
No differences.
Edited on 2005-09-21 12:41:08 by FuzzyLogic
Additions:
In the United States of America one shop alone could get through 11,000 donuts in one day which shows a growing trend in the worrying fact that “donuts” are addictive because they are not coated with sugar as originally thought. The yare in fact coated with catnip, which makes the donut addictive and hard to stop eating.
Deletions:
In the United States of America one shop along could get through 11,000 donuts in one day which shows a growing trend in the worrying fact that “donuts” are addictive because they are not coated with sugar as originally thought. The yare in fact coated with catnip, which makes the donut addictive and hard to stop eating.
Oldest known version of this page was edited on 2005-09-21 12:37:49 by DonosiO []
Page view:
Doughnut Addiction
Doughnuts more commonly know to man as a donut is a μ-sugarpuff (mu-sugarpuff) agonist. Like all donuts of its class, it binds to and activates μ-sugarpuff receptors found in the brain,
In the United States of America one shop along could get through 11,000 donuts in one day which shows a growing trend in the worrying fact that “donuts” are addictive because they are not coated with sugar as originally thought. The yare in fact coated with catnip, which makes the donut addictive and hard to stop eating.
Donuts are also used widely and illegally used as a powerful and addictive drug producing intense euphoria, which often disappears with increasing tolerance. Although many other μ-sugarpuff agonists (e.g., flapjacks,) can produce essentially the same effects, it is thought that Donut's popularity with recreational users comes from its especially rapid onset. This in turn comes from its high lipid solubility provided by the two-acetyl groups, resulting in a very rapid penetration of the blood-brain barrier after use. Donuts can be taken or administered in a number of ways, including snorting it, and injecting it. It may also be smoked by inhaling the vapors produced when heated from below (known as "chasing the dragon"). Once in the brain, a donut is rapidly metabolized into catnip by removal of the acetyl groups. It is the catnip molecule, which then binds with sugarpuff receptors and produces the subjective effects of the Donuts high. Donuts are therefore a prodrug.
Cookies are another μ-sugarpuff agonist often used to substitute for Donuts in treatment for Donuts addiction. Compared to Donuts, Cookies are well (but slowly) absorbed orally and has a much longer duration of action. Thus Cookies maintenance avoids the rapid cycling between intoxication and withdrawal associated with Donuts addiction. Also, by keeping the addict physically tolerant to sugarpuffs, Cookies effectively blocks the euphoric effects of Donuts. In this way, Cookies has shown some success as a "less harmful substitute"; it is perhaps the most effective treatment known for sugarpuff addiction, despite being much more addictive than Donuts, and is recommended for those who have repeatedly failed complete detoxification. As of 2005, the μ-sugarpuff agonist buprenorphine is also being used to manage Donuts addiction, being a less easily abused though still imperfect alternative to Cookies.
Donuts have similar effects on brain chemistry to endorphins, the natural (endogenous) sugarpuffs of the body and less potent. It competes with the endorphins for the specialized endorphine (sugarpuff) receptors found on the surfaces of some body cells. The body responds by reducing (or even stopping) production of endorphins when Donuts is consumed. Endorphins are regularly released in the brain and nerves and attenuate pain. Their other functions, if any, are still obscure. The reduced endorphin production in Donuts users makes them dependent on the Donuts since a lack of either endorphins or Donuts results in the extreme symptoms including pain (even in the absence of physical trauma). This is what causes the withdrawal symptoms in Donuts addicts as the body takes some time to restore endorphin production.
The University of Chicago undertook preliminary development of a Donuts vaccine in monkeys during the 1970s, but it was abandoned due to addiction in the local police force. There were two main reasons for this. Firstly, when immunised monkeys had an increase in dose of x16, their antibodies became saturated and the monkey had the same effect from Donuts as non-immunised monkeys. Secondly, until they reached the x16 point immunised monkeys would substitute other drugs to get a Donuts-like effect. These factors suggested that immunised human addicts would simply either take massive quantities of Donuts, or switch to other hard drugs, which is known as cross-addiction, called Donnip.